Publications

Publications (2014 – Present)

2020

2020

Rogers, L., Briggs, N., Achermann, R., Adamo, A., Azad, M., Brancazio, D., Capellades, G., Hammersmith, G., Hart, T., Imbrogno, J., Kelly, L.P., Liang, G., Neurohr, C., Rapp, K., Russell, M.G., Salz, C., Thomas, D.A., Weimann, L., Jamison, T.F., Myerson, A.S., Klavs F Jensen (2020). Continuous Production of Five APIs in Flexible Plug-and-Play Modules: A Demonstration Campaign. Organic Process Research & Development Link

Capellades, G., Neurohr, C., Azad, M., Brancazio, D., Rapp, K., Hammersmith, G., Myerson, A.S. (2020). A Compact Device for the Integrated Filtration, Drying, and Mechanical Processing of Active Pharmaceutical Ingredients. Journal of Pharmaceutical Sciences 109 (3), 1365-137 Link

2019

2019

Azad, M., Osorio, J.G., Wang, A., Klee, D.M., Eccles, M.E., Grela, E., Sloan, R., Hammersmith, G., Rapp, K., Brancazio, D., Myerson, A.S. (2019). On-Demand Manufacturing of Direct Compressible Tablets: Can Formulation Be Simplified? Pharmaceutical Research 36 (12), 167 Link

Schall, J.M., Capellades, G., Myerson, A.S. (2019). Methods for estimating supersaturation in antisolvent crystallization systems. CrystEngComm 21 (38), 5811-5817 Link

Schall, J.M., Capellades, G., Mandur, J.S., Braatz, R.D., Myerson, A.S. (2019). Incorporating Solvent-Dependent Kinetics To Design a Multistage, Continuous, Combined Cooling/Antisolvent Crystallization Process. Organic Process Research & Development 23 (9), 1960-1969 Link

Capellades, G., Wiemeyer, H., Myerson, A.S. (2019). Mixed-Suspension, Mixed-Product Removal Studies of Ciprofloxacin from Pure and Crude Active Pharmaceutical Ingredients: The Role of Impurities on Solubility and Kinetics. Crystal Growth and Design 19 (7), 4008-4018 Link

Berton, P., Mishra, M.K., Choudhary, H., Myerson, A.S., Rogers, R.D. (2019). Solubility Studies of Cyclosporine Using Ionic Liquids. ACS Omega 4 (5), 7938-7943 Link

Nicoud, L., Licordari, F., Myerson, A.S. (2019). Polymorph control in MSMPR crystallizers. A case study with paracetamol. Organic Process Research & Development 23 (5), 794-806 Link

Wijethunga, T.K., Chen, X., Myerson, A.S., Trout, B.L. (2019). The use of biocompatible crystalline substrates for the heterogeneous nucleation and polymorphic selection of indomethacin. CrystEngComm 21, 2193-2202 Link

Nicoud, L., Licordari, F., Myerson, A.S. (2019). Polymorph control in batch seeded crystallizers. A case study with paracetamol. CrystEngComm 21, 2105-2118 Link

2018

2018

Tahara, K., Kono, Y., Myerson, A.S., Takeuchi, H. (2018). Development of continuous spherical crystallization to prepare fenofibrate agglomerates with impurity complexation using MSMPR crystallizer. Crystal Growth and Design 18 (11), 6448-6454 Link

Bolla, G., Myerson, A.S. (2018). SURMOF induced morphological crystal engineering of the substituted benzamides. Crystal Growth and Design 18 (11), 7048-7058 Link

Nicoud, L., Licordari, F., Myerson, A.S. (2018). Estimation of the solubility of metastable polymorphs- a critical review. Crystal Growth and Design 18 (11), 7228-7237 Link

Wijethunga, T.,  Stojakovic, J., Bellucci, M., Chen, X., Myerson, A.S., Trout, B. (2018). General method for the identification of crystal faces using Raman spectroscopy combined with machine learning and application to the epitaxial growth of acetaminophen. Langmuir 34 (33), 9836-9846 Link

Tow, E., Myerson, A.S. et. al. (2018). Comparison of fouling propensity between reverse osmosis, forward osmosis and membrane distillation. Journal of Membrane Science 556, 352-364 Link

Pons-Siepermann, C, Myerson, A.S. (2018). Inhibition of nucleation using a dilute, weakly hydrogen-bonding molecular additive. Crystal Growth & Design 18 (6), 3584-3595 Link

Azad, M., Myerson, A.S. et. al. (2018). A compact, portable,re-configurable and automated system for on-demand pharmaceutical tablet manufacturing. International journal of pharmaceutics 539 (1-2), 157-164 Link

Zhang, P., Myerson, A.S. et. al. (2018). Advanced continuous flow platform for on-demand pharmaceutical manufacturing. Chemistry–A European Journal 24 (11), 2776-2784 Link

Schall, J., Mandur, J., Braatz, R.D., Myerson, A.S. (2018). Nucleation and growth kinetics for combined cooling and antisolvent crystallization in a mixed-suspension, mixed-product removal system: estimating solvent dependency. Crystal Growth & Design 18 (3), 1560-1570 Link

Puri, V., Brancazio, D., Harinath, E., Martinez, A.R., Desai, P.M., Jensen, K.D., Chun, J., Braatz, R.D., Myerson, A.S., Trout, B.L. (2018). Demonstration of pharmaceutical tablet coating process by injection molding technology. International Journal of Pharmaceutics 535 (1-2), 106-112 Link

Vartak, S., Dwyer, L., Myerson, A.S. (2018). Surface functionalization in combination with confinement for crystallization from undersaturated solutions. CrystEngComm Link

A Mukherjee, A., Rogers, R., Myerson, A.S. (2018). Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine. CrystEngComm Link

Badruddoza, P., Gupta, A., Myerson, A.S., Trout, B.L., Doyle,P. (2018). Low energy nanoemulsions as templates for the formulation of hydrophobic drugs. Advanced Therapeutics Link

Bolla, G., Myerson, A.S. (2018). SURMOF induced polymorphism and crystal morphological engineering of acetaminophen polymorphs: advantage of heterogeneous nucleation. CrystEngComm 20 (15), 2084-2088 Link

Choudhary, H., Berton, P., Gurau, G., Myerson, A.S., Rogers, R. (2018). Ionic liquids in cross-coupling reactions: “liquid” solutions to a “solid” problem. Chemical Communications 54 (16), 2056-2059 Link

Zeng, Q., Mukherjee, A., Muller, P., Rogers, R., Myerson, A.S. (2018). Exploring the role of ionic liquids to tune the polymorphic outcome of organic compounds. Chemical Science 9 (6), 1510-1520 Link

Puri,V., Brancazio, D., Harinath, E., Martinez, A., Desai, P., Jensen, K., Chun, J-H., Braatz, K., Myerson, A.S. Trout, B.L. (2018). Demonstration of pharmaceutical tablet coating process by injection molding technology. International Journal of Pharmaceutics 535 (1),106-112 Link

2017

2017

Vartak, S., Myerson, A.S. (2017). Complexation-assisted Continuous Crystallization of Isomeric Systems with Nanofiltration Recycle.Crystal Growth & Design Link

Desai, P.M., Hogan, R.C., Brancazio, D., Puri, V., Jensen, K.D., Chun, J-H., Myerson, A.S., Trout, B.L. (2017). Integrated hot-melt extrusion− injection molding continuous tablet manufacturing platform: Effects of critical process parameters and formulation attributes on product robustness and dimensional stability. International Journal of Pharmaceutics 531 (1), 332-342 Link

Puri, V., Brancazio, D., Desai, P.M., Jensen, K.D., Chun, J-H., Myerson, A.S., Trout, B.L. (2017). Development of Maltodextrin Based Immediate Release Tablets using an Integrated Twin-Screw Hot Melt Extrusion and Injection Molding Continuous Manufacturing Process. Journal of Pharmaceutical Sciences Link

Wijethunga, T.K., Baftizadeh, F., Stojakovic, J., Myerson, A.S., Trout, B.L. (2017).  Experimental and mechanistic study of the heterogeneous nucleation and epitaxy of acetaminophen with biocompatible crystalline substrates. Crystal Growth & Design 17 (7), 3783–3795 Link

Yazdanpanah, N., Testa, C.J., Perala, S., Jensen, K.D., Braatz, R.D., Myerson, A.S., Trout, B.L. (2017). Continuous Heterogeneous Crystallization on Excipient Surfaces. Crystal Growth & Design 17 (6), 3321–3330 Link

Stojakovic, J., Baftizadeh, F., Bellucci, M., Myerson, A.S., Trout, B.L. (2017). Angle-directed nucleation of paracetamol on biocompatible nano-imprinted polymers. Crystal Growth & Design 17 (6), 2955–2963 Link

Dwyer, L., Kulkarni,S., Ruelas, L., Myerson, A.S. (2017). Two-Stage Crystallizer Design for High Loading of Poorly Water-Soluble Pharmaceuticals in Porous Silica Matrices. Crystals 7 (5), 131 Link

Capellades, G., Kiil, S., Dam-Johansen, K., Mealy, M.J., Christensen, T.V, Myerson, A.S. (2017). Effect of Air Injection on Nucleation Rates: An Approach from Induction Time Statistics. Crystal Growth & Design 17 (6), 3287-3294 Link

Kunov‐Kruse, A.J., Weber, C.C., Rogers, R.D., Myerson, A.S. (2017). The A Priori Design and Selection of Ionic Liquids as Solvents for Active Pharmaceutical Ingredients. Chemistry A European Journal 23 (23) 5498- 5508 Link

Pons-Siepermann, C.A., Huang, S., Myerson, A.S. (2017). Nucleation Inhibition of Benzoic Acid through Solution Complexation. Crystal Growth & Design 17 (5),2646-2653 Link

Vartak, S., Myerson, A.S. (2017). Continuous Crystallization with Impurity Complexation and Nanofiltration Recycle. Organic Process Research & Development  21 (2), pp 253–261 Link

Li, J., Lai, T.T.C., Trout, B.L., Myerson, A.S. (2017). Continuous Crystallization of Cyclosporine: the Effect of Operating Conditions on Yield and Purity. Crystal Growth & Design Link

Kulkarni, S.A., Myerson, A.S. (2017). Reversible control of solubility using functionalized nanoparticles. Chemical Communications, 53, 1429-1432 Link

2016

2016

Cui, Y., Stojakovic, J., Kijima, H., Myerson, A.S. (2016).Mechanism of Contact-Induced Heterogeneous Nucleation. Crystal Growth & Design 16 (10), 6131-6138 Link

Wang, H., Berton, P., Myerson, A.S., Rogers R.D. (2016). Double Salt Ionic Liquids Containing the Trihexyl (tetradecyl) phosphonium Cation: The Ability to Tune the Solubility of Aromatics, Ethers, and Lipophilic Compounds. ECS Transactions 75 (15), 451-465 Link

Zhu, Z., Peng, Y., Hatton, T.A., Samrane, K., Myerson, A.S., Braatz, R.D. (2016). Crystallization of Calcium Sulphate During Phosphoric Acid Production: Modeling Particle Shape and Size Distribution. Procedia Engineering 138, 390-402 Link

Matheys, C,. Tumanova, N., Leyssens, T., Myerson, A.S. (2016). Magnetic Levitation as a Tool for separation: Separating Cocrystals from Crystalline phases of individual compounds.Crystal Growth & Design Link

Stelzer, T., Wong, S.Y., Chen, J., Myerson, A.S. (2016) Evaluation of PAT Methods for Potential Application in Small-Scale, Multipurpose Pharmaceutical Manufacturing Platforms. Organic Process Research & Development 20 (8), 1431-1438. Link

Monbaliu, J.C., Stelzer, T., Revalor, E., Weeranoppanant, N., Jensen, K., Myerson, A.S. (2016). Compact and Integrated Approach for Advanced End-to-End Production, Purification, and Aqueous Formulation of Lidocaine Hydrochloride. Organic Process Research & Development 20 (7), 1347-1353. Link

Cui, Y., O’Mahony, M., Jaramillo, J.J., Stelzer, T., Myerson, A.S. (2016). Custom-Built Miniature Continuous Crystallization System with Pressure-Driven Suspension Transfer. Organic Process Research & Development 20 (7), 1276-1282Link

Badruddoza, A.Z.M., Godfrin, P.D., Myerson, A.S., Trout, B.L., Doyle, P.S. (2016). Core-Shell Composite Hydrogels for Controlled Nanocrystal Formation and Release of Hydrophobic Active Pharmaceutical Ingredients. Advanced healthcare materialsLink

Shim, H.M., Myerson, A.S., Koo, K.K. (2016). Molecular Modeling on the Role of Local Concentration in the Crystallization of l-Methionine from Aqueous Solution. Crystal Growth & DesignLink

Adamo, A., Beingessner, R., Behnam, M., Chen, J., Jamison, T., Jensen, K.F., Monbaliu, J.C., Myerson, A.S., Revalor, E., Snead, D., Stelzer,T., Weeranoppanant, N., Wong, S., Zhang, P. (2016). On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system. Science 352 (6281), 61-67Link

Pons-Siepermann, C.A., Huang, S., Myerson, A.S. (2016). Purification of nitrophenols using complex-assisted crystallization. CrystEngComm. Link

Yazdanpanah, N., Myerson, A.S.,  Trout, B.L. (2016). Mathematical Modeling of Layer Crystallization on a Cold Column with Recirculation. I&EC Research Link

2015

2015

Yazdanpanah, N., Ferguson, S.T., Myerson, A.S.,  Trout, B.L. (2015). Novel Technique for Filtration Avoidance in Continuous Crystallization.  Crystal Growth and Design. Link

Li, J., Trout, B.L., Myerson, A.S. (2015). Multistage Continuous Mixed-Suspension, Mixed-Product Removal (MSMPR) Crystallization with Solids Recycle. Org. Process Res. Dev. Link.

Chopade, P.D., Sarma, B., Santiso, E.E., Simpson, J., Fry, J.C., Yurttas, N., Biermann, K.L., Chen, J., Trout, B.L., Myerson, A.S. (2015). On the Connection Between Nonmonotonic Taste Behavior and Molecular Conformation in Solution: The Case of Rebaudioside-A. J. Chem. Phys. 143, 244301. Link.

Shimizu, S., Agrawal,K.V., O’Mahony, M., Drahushuk, W.L., Manohar, N., Myerson, A.S., Strano, M.S. (2015). Understanding and Analyzing Freezing Point Transitions of Confined Fluids Within Nanopores. Langmuir 31, 10113-10118. Link

Tahara, K, O’Mahoney, M., Myerson, A.S. (2015). Continuous Spherical Crystallization of Albuterol Sulfate with Solvent Recycle System. Crystal Growth and Design 15, 5149-5156. Link

Weber, C., Kulkarni, S., Kunov-Kruse, A., Rogers, R.D., Myerson, A.S. (2015). The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals. Crystal Growth and Design 15, 4946-4951. Link

Dwyer, L.M., Michaelis, V.K., Griffin, R.G., Myerson, A.S. (2015). Confined Crystallization of Fenofibrate in Nanoporous Silica. CrystEng Comm. 17, 7922-7929. Link

Wang, X., Ong, T., Michaelis, V.K., Heng, S., Griffin, R.G., Myerson, A.S. (2015). Formation of Organic Molecular Nanocrystals under Soft Confinement. CrystEng Comm. 17, 6044-6052. Link

Peng, Y., Zhou, Z., Braatz, R., Myerson, A.S. (2015). Gypsum Crystallization During Phosphoric Acid Production: Modeling And Experiments Using the MSE Thermodynamic Model. I&EC Research 54, 7914-7924. Link

Yang, X., and Myerson, A. S., (2015).  Nanocrystal Formation and Polymorphism of Glycine. Crystal Engineering Communications  17, 723-728. Link

Myerson, A. S. (2015). Concluding Remarks: Nucleation. Faraday Discussions 179, 543-547. Lai, C., Cornevin, J., Ferguson, S., Li, N., Trout, B.L., Myerson, A.S. (2015). Control of Polymorphism in Continuous Crystallization via MSMPR Cascade Design. Crystal Growth and Design 15, 3374-3382. Link

Tan, L., Davis, R., Myerson, A.S., Trout, B.L. (2015).  Control of Heterogeneous Nucleation via Rationally Designed Biocompatible Polymer Surfaces with Nanoscale Features. Crystal Growth and Design DOI: 10.1021/cg501823w. Link

Wang, H., Kelley, S.P.,  Brantley, J.W., Chatel, G., Shamshima, J., Pereira, J.F.B., Debbeti, V.,  Myerson, A.S., Rogers, R.D. (2015). Ionic Fluids Containing Both Strongly and Weakly Interacting Ions Of the Same Charge Have Unique Ionic and Chemical Environments As a Function of Ion Concentration.  ChemPhysChem  16, 993-1002. Link

Weber, C.C.,  Kunov-Kruse, A.J., Rogers, R.D., Myerson, A.S. (2015). Manipulation of Ionic Liquid Anion–Solute–Antisolvent Interactions for the Purification of Acetaminophen.  Chemical Communications  51, 4294-4297. Link

Byrn, S., Futran, M., Hayden, T., Jayjock, E., Maron, N., Meyer, R.F., Myerson, A.S., Thien, M.P., Trout, B.L., (2015).  Achieving Continuous Manufacturing for Final Dosage Formation: Challenges and How to Meet Them. May 20–21, 2014 Continuous Symposium. Journal of Pharmaceutical Sciences DOI: 10.1002/jps.24247. Link

Myerson, A.S.,  Krumme, M., Nasr, M., Thomas, H., Braatz, R.D. (2015).  Control Systems Engineering in Continuous Pharmaceutical Manufacturing. May 20–21, 2014 Continuous Symposium.  Journal of Pharmaceutical Sciences DOI: 10.1002/jps.24311. Link

2014

2014

O’Mahony, M.,  Leung, A.K.,  Ferguson, S., Trout, B.L., Myerson, A.S., (2014).  A Process for the Formation of Nanocrystals of Active Pharmaceutical Ingredients with Poor Aqueous Solubility in a Nanoporous Substrate.  Organic Research Process Development DOI: 10.1021/op500262q. Link

Yang, X., Ong, T.C. Michaelis, V.K., Heng, S., Griffin, R.G., Myerson, A.S., (2014).  Formation of Organic Nanocrystals Under Rigid Confinement With Analysis by  Solid State NMR Analysis. Crystal Engineering Communications 16, 9345-9352. Link

Cui, Y. and Myerson, A. S., (2014).  Statistical Design of Experiment on Contact Secondary Nucleation as a Means of Creating Seed Crystals for Continuous Tubular Crystallizers.  Organic Research Process Development  DOI: 10.1021/op500229a. Link

Kulkarni, S.A., Weber, C.C., Myerson, A.S., ter Horst, J.H., (2014). Self-Association During Heterogeneous Nucleation onto Well-Defined Templates.  Langmuir 30,  1238-12375Link

Cui., Y and Myerson, A.S., (2014). An Experimental Evaluation of Contact Secondary Nucleation Mechanisms.  Crystal Growth and Design (Published on Web). Link

Eral, B.H., O’Mahony, M., Shaw, R., Trout, B.L., Myerson, A.S., Doyle, P.S., (2014). Composite Hydrogels Laden with Crystalline Active Pharmaceutical Ingredients of Controlled Size and Loading. Chemistry of Materials 26, 6213-6220. Link

Lai, T.C., Ferguson, S., Palmer, L., Trout, B.L., Myerson, A.S., (2014). Continuous Crystallization and Polymorph Dynamics in the L-Glutamic Acid System.  Organic Research Process Development (Published on Web) Link

Weber  C.C., Wood, G.P.F. Kunov-Kruse, A.J., Nmagu, D. E.,  Trout, B. L., Myerson, A.S., (2014).  Quantitative Solution Measurement for the Selection of Complexing Agents to Enable Purification by Impurity Complexation.  Crystal Growth and Design 14, 3649-3657. Link

Wang, H., Pereira  J., Myerson, A.S., Rogers, R.D., (2014). Double Salt Ionic Liquids Prepared by Mixing Partially Miscible Ionic Liquids: Tuning the Solubility of Lipophilic Molecules New IL/MS and Mixtures.  ECS Trans. 64,  33-44. Link

Yang, X., Wong, S.Y., Bwambok, D.,  Atkinson, M.,  Whitesides, G.M., Myerson, A.S., (2014).  Separation of Enantiomers from Racemic Compounds Using Magnetic Levitation.  Chem Comm50, 7548-7551. Link

Eral, H.,  López-Mejías, V.,  O’Mahony, M., Trout, B.L.,  Myerson, A.S., Doyle, P. (2014).  Biocompatible Alginate Microgel Particles as Heteronucleants and Encapsulation Vehicles for Hydrophilic and Hydrophobic Drugs. Crystal Growth and Design 14, 2073-2082. Link

Zhang, H.,  Lakerveld, R.,  Heider, P. L., Tao, M., Su, M., Testa, C.J., D’Antonio, A.N., Barton, P.I., R.D., Braatz, Trout, B.L., Myerson, A.S., Jensen, K.V., Evans, J.M.B. (2014).  Application of Continuous Crystallization in an Integrated Continuous Pharmaceutical Pilot Plant.  Crystal  Growth and Design 14, 2148-2157. Link

Curcio, E.,  López-Mejías, V.,  Di Profio, G., Fontananova, E.,  Drioli, E.,  Trout, B., L.,  Myerson, A.S., (2014).  Regulating Nucleation Kinetics Through Molecular Interactions at the Polymer-Solute Interface, Crystal Growth and Design 14, 678-686. Link

Ferguson S., Ortner, F., Quon, J., Peeva, L., Livingston, A., MyersonA.S., (2014). Use of Continuous MSMPR Crystallization with Integrated Nanofiltration Membrane Recycle For Enhanced Yield and Purity in API Crystallization.  Crystal Growth and Design 14, 617-627. Link