Publications (2011 – 2015)

Yazdanpanah, N., Ferguson, S.T., Myerson, A.S.,  Trout, B.L. (2015). Novel Technique for Filtration Avoidance in Continuous Crystallization.  Crystal Growth and Design. Link

Li, J., Trout, B.L., Myerson, A.S. (2015). Multistatge Continuous Mixed-Suspension, Mixed-Product Removal (MSMPR) Crystallization with Solids Recycle. Org. Process Res. Dev. Link.

Chopade, P.D., Sarma, B., Santiso, E.E., Simpson, J., Fry, J.C., Yurttas, N., Biermann, K.L., Chen, J., Trout, B.L., Myerson, A.S. (2015). On the Connection Between Nonmonotonic Taste Behavior and Molecular Conformation in Solution: The Case of Rebaudioside-A. J. Chem. Phys. 143, 244301. Link.

Shimizu, S., Agrawal,K.V., O’Mahony, M., Drahushuk, W.L., Manohar, N., Myerson, A.S., Strano, M.S. (2015). Understanding and Analyzing Freezing Point Transitions of Confined Fluids Within Nanopores. Langmuir 31, 10113-10118. Link

Tahara, K, O’Mahoney, M., Myerson, A.S. (2015). Continuous Spherical Crystallization of Albuterol Sulfate with Solvent Recycle System. Crystal Growth and Design 15, 5149-5156. Link

Weber, C., Kulkarni, S., Kunov-Kruse, A., Rogers, R.D., Myerson, A.S. (2015). The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals. Crystal Growth and Design 15, 4946-4951. Link

Dwyer, L.M., Michaelis, V.K., Griffin, R.G., Myerson, A.S. (2015). Confined Crystallization of Fenofibrate in Nanoporous Silica. CrystEng Comm. 17, 7922-7929. Link

Wang, X., Ong, T., Michaelis, V.K., Heng, S., Griffin, R.G., Myerson, A.S. (2015). Formation of Organic Molecular Nanocrystals under Soft Confinement. CrystEng Comm. 17, 6044-6052. Link

Peng, Y., Zhou, Z., Braatz, R., Myerson, A.S. (2015). Gypsum Crystallization During Phosphoric Acid Production: Modeling And Experiments Using the MSE Thermodynamic Model. I&EC Research 54, 7914-7924. Link

Myerson, A. S. (2015). Concluding Remarks: Nucleation. Faraday Discussions 179, 543-547. Lai, C., Cornevin, J., Ferguson, S., Li, N., Trout, B.L., Myerson, A.S. (2015). Control of Polymorphism in Continuous Crystallization via MSMPR Cascade Design. Crystal Growth and Design 15, 3374-3382. Link

Tan, L., Davis, R., Myerson, A.S., Trout, B.L. (2015).  Control of Heterogeneous Nucleation via Rationally Designed Biocompatible Polymer Surfaces with Nanoscale Features. Crystal Growth and Design DOI: 10.1021/cg501823w. Link

Wang, H., Kelley, S.P.,  Brantley, J.W., Chatel, G., Shamshima, J., Pereira, J.F.B., Debbeti, V.,  Myerson, A.S., Rogers, R.D. (2015). Ionic Fluids Containing Both Strongly and Weakly Interacting Ions Of the Same Charge Have Unique Ionic and Chemical Environments As a Function of Ion Concentration.  ChemPhysChem  16, 993-1002. Link

Weber, C.C.,  Kunov-Kruse, A.J., Rogers, R.D., Myerson, A.S. (2015). Manipulation of Ionic Liquid Anion–Solute–Antisolvent Interactions for the Purification of Acetaminophen.  Chemical Communications  51, 4294-4297. Link

Byrn, S., Futran, M., Hayden, T., Jayjock, E., Maron, N., Meyer, R.F., Myerson, A.S., Thien, M.P., Trout, B.L., (2015).  Achieving Continuous Manufacturing for Final Dosage Formation: Challenges and How to Meet Them. May 20–21, 2014 Continuous Symposium. Journal of Pharmaceutical Sciences DOI: 10.1002/jps.24247. Link

Myerson, A.S.,  Krumme, M., Nasr, M., Thomas, H., Braatz, R.D. (2015).  Control Systems Engineering in Continuous Pharmaceutical Manufacturing. May 20–21, 2014 Continuous Symposium.  Journal of Pharmaceutical Sciences DOI: 10.1002/jps.24311. Link

O’Mahony, M.,  Leung, A.K.,  Ferguson, S., Trout, B.L., Myerson,A.S., (2014).  A Process for the Formation of Nanocrystals of Active Pharmaceutical Ingredients with Poor Aqueous Solubility in a Nanoporous Substrate.  Organic Research Process Development DOI: 10.1021/op500262q. Link

Yang, X., Ong, T.C. Michaelis, V.K., Heng, S., Griffin, R.G., Myerson, A.S., (2014).  Formation of Organic Nanocrystals Under Rigid Confinement With Analysis by  Solid State NMR Analysis. Crystal Engineering Communications 16, 9345-9352. Link

Yang, X., and Myerson, A. S., (2015).  Nanocrystal Formation and Polymorphism of Glycine. Crystal Engineering Communications  17, 723-728. Link

Cui, Y. and Myerson, A. S., (2014).  Statistical Design of Experiment on Contact Secondary Nucleation as a Means of Creating Seed Crystals for Continuous Tubular Crystallizers.  Organic Research Process Development  DOI: 10.1021/op500229a. Link

Kulkarni, S.A., Weber, C.C., Myerson, A.S., ter Horst, J.H., (2014). Self-Association During Heterogeneous Nucleation onto Well-Defined Templates.  Langmuir 30,  1238-12375. Link

Cui., Y and Myerson, A.S., (2014). An Experimental Evaluation of Contact Secondary Nucleation Mechanisms.  Crystal Growth and Design (Published on Web). Link

Eral, B.H., O’Mahony , M., Shaw, R., Trout, B.L., Myerson, A.S., Doyle, P.S., (2014). Composite Hydrogels Laden with Crystalline Active Pharmaceutical Ingredients of Controlled Size and Loading. Chemistry of Materials 26, 6213-6220. Link

Lai, T.C., Ferguson , S., Palmer, L., Trout, B.L., Myerson, A.S., (2014). Continuous Crystallization and Polymorph Dynamics in the L-Glutamic Acid System.  Organic Research Process Development (Published on Web) Link

Weber  C.C., Wood, G.P.F. Kunov-Kruse, A.J., Nmagu, D. E.,  Trout, B. L., Myerson, A.S., (2014).  Quantitative Solution Measurement for the Selection of Complexing Agents to Enable Purification by Impurity Complexation.  Crystal Growth and Design 14, 3649-3657. Link

Wang, H., Pereira  J., Myerson, A.S., Rogers, R.D., (2014). Double Salt Ionic Liquids Prepared by Mixing Partially Miscible Ionic Liquids: Tuning the Solubility of Lipophilic Molecules New IL/MS and Mixtures.  ECS Trans. 64,  33-44. Link

Yang, X., Wong, S.Y., ,Bwambok, D.,  Atkinson, M.,  Whitesides, G.M., Myerson, A.S., (2014).  Separation of Enantiomers from Racemic Compounds Using Magnetic Levitation.  Chem Comm. 50, 7548-7551. Link

Eral, H.,  López-Mejías, V.,  O’Mahony, M., Trout, B.L.,  Myerson, A.S., Doyle, P. (2014).  Biocompatible Alginate Microgel Particles as Heteronucleants and Encapsulation Vehicles for Hydrophilic and Hydrophobic Drugs. Crystal Growth and Design 14, 2073-2082. Link

Zhang, H.,  Lakerveld, R.,  Heider, P. L., Tao, M., Su, M., Testa, C.J., D’Antonio, A.N., Barton, P.I., R.D., Braatz, Trout, B.L., Myerson, A.S., Jensen, K.V., Evans, J.M.B. (2014).  Application of Continuous Crystallization in an Integrated Continuous Pharmaceutical Pilot Plant.  Crystal  Growth and Design 14, 2148-2157. Link

Curcio, E.,  López-Mejías, V.,  Di Profio, G., Fontananova, E.,  Drioli, E.,  Trout, B., L.,  Myerson, A.S., (2014).  Regulating Nucleation Kinetics Through Molecular Interactions at the Polymer-Solute Interface, Crystal Growth and Design 14, 678-686. Link

Ferguson S., Ortner, F., Quon, J., Peeva, L., Livingston, A., Myerson, A.S., (2014). Use of Continuous MSMPR Crystallization with Integrated Nanofiltration Membrane Recycle For Enhanced Yield and Purity in API Crystallization.  Crystal Growth and Design 14, 617-627. Link

Myerson, A.S., and Trout, B.L., (2013). Nucleation from Solution. Science 341, 855-856. Link

Shi, X., Wong, S.Y., Yang, X., and Myerson, A.S., (2013). Concomitant Cocrystallization on Engineered Surfaces. CrystEngComm 15, 7450- 7455. Link

Mascia, S., Heider, P.L., Zhang, H., Lakerveld, R., Benyahia, B., Barton, P.I., Braatz, R.D., Cooney, C.L., Evans, J.M.B., Jamison, T.F. Jensen, K.F., Myerson, A.S., and Trout, B.L., (2013). End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation. Angewandte Chemie International Edition, Vol. 52, Issue 47, 12359-12363. Link

Atkinson,, M.B.J., Bwambok, B.K., Chen, J., Chopode, P.D., Thuo, M.M., Mace, C.R., Mirica, K.A., Kumar, A.A., Myerson, A.S., Whitesides, G.M., (2013). Using Magnetic Levitation to Separate Crystals of Polymorphs. Angewandte Chemie International Edition (published on web). Link

Wang, H., Gurau, G., Kelley, S.P., Myerson, A.S., Rogers, R.D., (2013). Hydrophobic vs. Hydrophilic Ionic Liquid Separations Strategies in Support of Continuous Pharmaceutical Manufacturing. RSC Advances 3, 10019-10026. Link

Hsi, K., Concepcion , A.J., Kenny, M., Magzoub, A.A, Myerson, A.S., (2013). Purification of Amoxicillin Trihydrate by Impurity-Coformer Complexation in Solution. CrystEng Comm. 15, 6776-6781. Link

López-Mejías, V., Myerson, A.S., Trout, B.L., (2013). Geometric Design of Heterogeneous Nucleation Sites on Biocompatible Surfaces. Crystal Growth and Design 13. 3835-3841. Link

Zhou, L., Su, M., Benyahia, B., Singh, A.,  Barton, P.I., Trout, B.L., Myerson, A.S.,and Braatz, R.L. (2013). Mathematical Modeling and Design of Layer Crystallization in a Concentric Annulus with and without Recirculation.  AICHE J, Vol. 59, Issue 4, 1308-1321. Link

Quon, J.L., Chadwick, K., Wood, G.P.F., Sheu, I., Brettmann, B.K ., Myerson, A.S., Trout, B.L. (2013).  Templated Nucleation of Acetaminophen on Spherical Excipient Agglomerates.  Langmuir, 2013, 29(10), pp 3292-3300. Link

Brettmann, B.K.,  Cheng, K., Myerson, A.S., Trout, B.L., (2013). Electrospun formulations containing crystalline active pharmaceutical ingredients. Pharmaceutical Research 1, 238-246. Link

Hsi, K.,  Kenny, M., Simi, A., Myerson, A.S., (2013).  Purification of Structurally Similar Compounds by the Formation of Impurity Co – former Complexes in Solution.  Crystal Growth and Design, 2013, 13(4), pp 1577-1582. Link

Wong, S.Y., Chen, J., Forte, L and Myerson, A.S., (2013). Compact Crystallization, Filtration and Drying for the Production of Active Pharmaceutical Ingredients. Organic Process Research and Development, 2013 17(4), pp 684-692. Link

Wong, S.Y., Cui, Y., and Myerson, A.S., (2013). Contact Secondary Nucleation as a Means of Creating Seeds for Continuous Tubular Crystallizers. Crystal Growth and Design 13, 2514-2521. Link

Chadwick, K, Chen, J, Myerson, A.S., and Trout, B.L. (2012).  Toward the Rational Design of Crystalline Surfaces for Heteroepitaxy: Role of Molecular Functionality.  Crystal Growth and Design  12, 1159-1166. Link

Diao, Y., Whaley, K.E.,  Helgeson, M.E., Woldeyes, M.A., Doyle, P.S., Myerson, A.S.,  Hatton, T.A., and Trout, B.L. (2012). Gel Induced Selective Crystallization of Polymorphs.  JACS 134, 673-684. Link

Brettman, B., Bell, E., Myerson, A.S., and Trout, B.L. (2012).  Solid state NMR characterization of high-loading solid solutions of API and excipients formed by electrospinning. J. Pharm. Sci. 101, 1538-1545. Link

Zhang, H., Quon, J.,  Alvarez, A., ; Evans, J.M.,  Myerson, A.S., and Trout, B.L.  (2012). Development of Continuous Anti-solvent-cooling Crystallization Process Using Cascaded MSMPR Crystallizer. Organic Research Process and Development  16, 915-924. Link

Hsi, H.Y., Chadwick, K., Fried, A, Kenny, M., and Myerson, A.S. (2012).  Separation of Impurities from Solution by Selective Co-Crystal Formation. Cryst. Eng. Comm.  14, 2386-2388. Link

Brettmann, B.K., Tsang, S., Forward, K.M.,  Rutledge, G.C., Myerson, A.S., and Trout, B.L. (2012).  Free Surface Electrospinning of Fibers Containing Nanoparticles.  Langmuir 28, 9714-9721. Link

Brettmann, B.K., Myerson, A.S., and Trout, B.L. (2012).  Solid State Nuclear Magnetic Resonance Study of the Physical Stability of Electrospun Drug and Polymer Solid Solutions.  J. Pharm. Sci. 101, 2185-2193. Link

Quon, J.L., Zhang,H., Alvarez, A., Evans, J.M.,  Myerson, A.S., Trout, B.L., (2012).  Continuous Crystallization of Aliskiren Hemifumarate. Crystal Growth and Design 12, 3036-3044. Link

Zaworotko, M.J., Aitipamula, S.,  Banerjee, R.,  Bansal, A.K., Biradha, K., Cheney,  M. Roychoudhury, A.,  Desiraju, D., Dikundwar, A., Dubey, R., Duggirala, N., Ghogale,  P., Ghosh,  S., Goswami, P.K. Goud, R.,  Jetti, R.,  Karpinski, P., Kaushik, P., Shukla, D.S., Kumar, V., Moulton, B., Mukherjee, A., Mukherjee, G., Myerson, A.S, Rajamannar, T., Ramanan, A.,  Reddy, C.M., Rodríguez-Hornedo, N., Rogers, R.D., Narasingarao, T., Row, T., Sanphui, P., Shan, N., Shete, G., Singh, A., Sun, C.C.,  Swift, J.A., Thaimattam, R., Singh, Thakur, T.S., Thaper, R.K., Thomas, S.P., Tothadi, S., Vangala, V.R., Variankaval, N., Peddy,  V., Weyna, D. (2012).  Polymorphs Salts and Cocrystals:  What’s in a Name?  Crystal Growth and Design 12, 2147-2152. Link

Chen, J., and Myerson, A.S. (2012).  Pasteur Revisited: Chiral Separation by Crystallization on Self-Assembled Monolayers.  Cryst Eng Communications 14, 8326-8329. Link

Yang, X., Sarma, B., and Myerson, A.S., (2012).  Polymorph Control of Micro/Nano Sized Mefenamic Acid Crytals on Patterned Self Assembled Monolayers. Crystal Growth and Design 12, 5521-5528. Link

Wong, S.Y., Tatusko, A., Trout, B.L., and Myerson, A.S.  (2012). Development of Continuous Crystallization Processes Using a Single Stage MSMPR Crystallizer with Recycle. Crystal Growth and Design 12, 5701-5707. Link

Diao, Y., Hegelson, M.E., Siam, Z.A., Doyle, P.S., Myerson, A.S., Hatton, T. A., and Trout, B.L. (2012). Nucleation under Soft Confinement: Role of Polymer-Solute Interactions. Crystal Growth and Design 12, 508-517. Link

Wang, M., Rutledge, G.C., Myerson, A.S., and Trout, B.L. (2012). Production and Characterization of Carbamezapine Nanocrystals by Electrospraying. J. Pharm. Sci. 101, 1178-1188. Link

Chen, J., Sarma, B., Evans, J.M.B., and Myerson, A.S. (2011). Pharmaceutical Crystallization. Crystal Growth and Design 11, 887-895. Link

Diao, Y., Myerson, A.S., Hatton, T.A., and Trout, B. L. (2011). Surface Design for Controlled Crystallization: The Role of Surface Chemistry and Nanoscale Pores in Heterogeneous Nucleation. Langmuir 27, 5324-5334. Link

Diao, Y., Hegelson, M.E., Myerson, A. S., Hatton, T. A.,  Doyle, P. S., and Trout, B.L.  (2011).  Controlled Nucleation from Solution Using Polymer Microgels.  Journal of the American Chemical Society 133, 3756-3759. Link

Lee, A.Y., Erdemir, D, Myerson, A.S. (2011). Crystal Polymorphism in Chemical Process Development. The Annual Review of Chemical and Biomolecular Engineering 2, 259-280. Link

Diao, Y., Harada, T., Myerson, A.S., Hatton, T.A., and Trout. B.L. (2011). The Role of Pore Shape on Surface-Induced Crystallization. Nature Materials 10, 867-871. Link

Antwi, M., Myerson, A.S., and Zurawsky, W. (2011). Diffusion of Lysozyme in Buffered Salt Solutions. Industrial and Engineering Chemistry Research 50, 10313-10319. Link

Alvarez, A., Singh, A., and Myerson, A.S. (2011). Crystallization of Cyclosporine in a Continuous Multistage MSMPR Crystallizer. Crystal Growth and Design 11, 4392-4400. Link

Chadwick, K, Myerson, A.S., and Trout, B.L. (2011). Polymorph Control by Heterogeneous Nucleation – A New Method of Selecting Crystalline Substrates. Cryst. Eng. Comm. 13, 6625-6627. Link

Chadwick, K, Chen, J, Myerson, A.S., and Trout, B.L. (2011). Toward the Rational Design of Crystalline Surfaces for Heteroepitaxy: Role of Molecular Functionality. Crystal Growth and Design, 12, 1159-1166. Link

Hsi, H.Y., Chadwick, K., Fried, A, Kenny, M., and Myerson, A.S. (2011). Separation of Impurities from Solution by Selective Co-Crystal Formation. Cryst. Eng. Comm. 14(7), 2386-2388. Link

Lee, S., Choi, A., Kim, W.S., and Myerson, A.S. (2011). Phase Transformation of Sulfamerazine using a Taylor Vortex. Crystal Growth and Design 11, 5019-5029. Link

Chen J., Sarma B., Evans J. M.B., and Myerson A.S. (2011) Pharmaceutical Crystallization. Crystal Growth and Design (published on web). Link

Sarma B., Chen J., Hsi, H.Y., and Myerson A.S. (2011) Solid forms of pharmaceuticals: Polymorphs, salts and cocrystals. Korean Journal of Chemical Engineering, 28, 315-322. Link

Kim, K, Centrone, A., Hatton, T.A., and Myerson, A.S. (2011) Polymorphism control of nanosized glycine crystals on engineered surfaces. Cryst. Eng. Comm. 13, 1127-1131. Link